Cyclin D1 anticorps (AA 68-97)
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- Antigène Voir toutes Cyclin D1 (CCND1) Anticorps
- Cyclin D1 (CCND1)
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Épitope
- AA 68-97
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Cyclin D1 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Homologie
- B
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogène
- This Cyclin D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-97 amino acids from human Cyclin D1.
- Clone
- RB8066
- Isotype
- Ig Fraction
- Top Product
- Discover our top product CCND1 Anticorps primaire
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- Indications d'application
- IF: 1:10~50. WB: 1:1000. WB: 1:2000. WB: 1:2000. IHC-P: 1:25
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Date de péremption
- 6 months
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HNF4? is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer." dans: Gut, (2014) (PubMed).
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HNF4? is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer." dans: Gut, (2014) (PubMed).
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- Antigène
- Cyclin D1 (CCND1)
- Autre désignation
- Cyclin D1 (CCND1 Produits)
- Sujet
- CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. It has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
- Poids moléculaire
- 33729
- ID gène
- 595
- NCBI Accession
- NP_444284
- UniProt
- P24385
- Pathways
- Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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