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PCNA anticorps (C-Term)

Name: PCNA anticorps (C-Term)
SKU: ABIN389344
Price: 445.5 EUR
Availability: InStock

PCNA Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal RB17486 unconjugated

Western blot analysis of PCNA Antibody (C-term) (ABIN389344 and ABIN2839453) in Jurkat, Hela, 293 cell line lysates (35 μg/lane). (PCNA anticorps (C-Term))

PCNA Antibody (C-term) (ABIN389344 and ABIN2839453) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. (PCNA anticorps (C-Term))

IHC (p)

Confocal immunofluorescent analysis of PCNA Antibody (C-term) (ABIN389344 and ABIN2839453) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (PCNA anticorps (C-Term))

Confocal immunofluorescent analysis of PCNA Antibody (C-term) (ABIN389344 and ABIN2839453) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (PCNA anticorps (C-Term))

Western blot analysis of PCNA (arrow) using rabbit polyclonal PCNA Antibody (C-term) (ABIN389344 and ABIN2839453). (PCNA anticorps (C-Term))

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PCNA antibody (C-term) (ABIN389344 and ABIN2839453) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (PCNA anticorps (C-Term))

IHC (p)

6 images

(5 références)

N° du produit ABIN389344

Fiche de données

Antigène Voir toutes PCNA Anticorps

PCNA (Proliferating Cell Nuclear Antigen (PCNA))
Épitope
16

16

16

15

12

11

8

6

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 231-261, C-Term
Reactivité
218

161

160

54

28

28

21

19

19

18

17

15

11

10

6

6

5

5

4

4

4

3

3

3

2

2

2

2

2

1

1

1

1
Humain
Hôte
134

97

3
Lapin
Anticorps secondaires appropriés
Clonalité
135

98

1
Polyclonal
Conjugué
111

17

13

8

5

5

5

5

5

5

5

5

5

5

5

4

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1
Cet anticorp PCNA est non-conjugé
Application
190

68

65

60

56

46

46

40

31

15

15

12

5

4

3

2

2

2

2

2

1

1

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie

B, Ha, Pr, Rat

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène

This PCNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-261 amino acids from the C-terminal region of human PCNA.

Clone

RB17486

Isotype

Ig Fraction

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anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) antibody
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anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 201-261) antibody
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anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 6-261) antibody
PCNA Reactivité: Humain, Souris, Rat, Porc, Lapin, Chien, Macaque rhésus WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) antibody
PCNA Reactivité: Humain WB, IHC, IHC (p) Hôte: Souris Monoclonal 1H10 unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) antibody
PCNA Reactivité: Humain WB, IHC, IF, IP Hôte: Lapin Monoclonal unconjugated

Indications d'application

IF: 1:10~50. IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:10~50

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C,-20 °C

Stockage commentaire

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption

6 months
Deng, Xu, Zou, Shen, Peng, Liu, Engelhardt, Yan, Qiu: "DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells." dans: Journal of virology, Vol. 91, Issue 1, (2017) (PubMed).

Lei, Li, Luo: "Liuweiwuling tablets attenuate acetaminophen-induced acute liver injury and promote liver regeneration in mice." dans: World journal of gastroenterology : WJG, Vol. 21, Issue 26, pp. 8089-95, (2015) (PubMed).

Ding, Ko, Pehar, Kotch, Peters, Luo, Salamat, Puglielli: "Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces ?-secretase (BACE1) levels and A? generation." dans: The Journal of biological chemistry, Vol. 287, Issue 11, pp. 8424-33, (2012) (PubMed).

Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." dans: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).

Li, Li, Zhang, Bai, Wang, Zhao, Jonas: "Lentiviral vector-mediated PAX6 overexpression promotes growth and inhibits apoptosis of human retinoblastoma cells." dans: Investigative ophthalmology & visual science, Vol. 52, Issue 11, pp. 8393-400, (2011) (PubMed).
Antigène

PCNA (Proliferating Cell Nuclear Antigen (PCNA))

Autre désignation

PCNA (PCNA Produits)

Synonymes

anticorps PCNAR, anticorps Pcna/cyclin, anticorps pcna, anticorps AO090003000846, anticorps 53/13, anticorps CG9193, anticorps DmPCNA, anticorps Dmel\\CG9193, anticorps MUS209, anticorps Mus209, anticorps PCNA, anticorps PCNA/mus209, anticorps Pcna, anticorps dPCNA, anticorps l(2)02448, anticorps l(2)56F, anticorps l(2)56Fa, anticorps l(2)s1534, anticorps cb16, anticorps fb36g03, anticorps wu:fa28e03, anticorps wu:fb36g03, anticorps pcna-A, anticorps proliferating cell nuclear antigen, anticorps DNA polymerase III sliding clamp, anticorps Proliferating cell nuclear antigen, anticorps Proliferating cell nuclear antigen-like, anticorps proliferating cell nuclear antigen L homeolog, anticorps proliferating cell nuclear antigen 1, anticorps PCNA, anticorps Pcna, anticorps pcna, anticorps MMP_RS08810, anticorps ANI_1_512014, anticorps AOR_1_1500154, anticorps MGC53867, anticorps pcna.L, anticorps pcna1, anticorps LOC106420145, anticorps pcn1

Sujet

PCNA is found in the nucleus and is a cofactor of DNA polymerase delta. This protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway.

Poids moléculaire

28769

ID gène

5111

NCBI Accession

NP_002583, NP_872590

UniProt

P12004

Pathways

Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy