RAD9A anticorps (pSer328)

N° du produit ABIN389633

Détail du produit anti-RAD9A anticorps

Antigène: RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))

Épitope: pSer328

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD9A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This RAD9 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S328 of human RAD9.

Clone: RB7115

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100. DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-RAD9A (ABIN389633)

Awate, De Benedetti: "TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint." dans: BMC molecular biology, Vol. 17, pp. 3, (2016) (PubMed).

Ronald, Awate, Rath, Carroll, Galiano, Dwyer, Kleiner-Hancock, Mathis, Vigod, De Benedetti: "Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy." dans: Genes & cancer, Vol. 4, Issue 1-2, pp. 39-53, (2013) (PubMed).

Détails sur RAD9A

Antigène: RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))

Autre désignation: RAD9 (RAD9A Produits)

Synonymes: anticorps RAD9, anticorps Rad9, anticorps rad9a, anticorps MGC89062, anticorps XRad9, anticorps rad9, anticorps RAD9 checkpoint clamp component A, anticorps RAD9 checkpoint clamp component B, anticorps RAD9 checkpoint clamp component A L homeolog, anticorps RAD9A, anticorps Rad9a, anticorps rad9a, anticorps rad9b, anticorps rad9a.L

Sujet: Rad9 is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade.

Poids moléculaire: 42547

ID gène: 5883

NCBI Accession: NP_001230153, NP_004575

UniProt: Q99638

Pathways: Positive Regulation of Response to DNA Damage Stimulus