RAPTOR anticorps (pSer863)

N° du produit ABIN389879

Détail du produit anti-RAPTOR anticorps

Antigène: RAPTOR

Épitope: pSer863

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAPTOR est non-conjugé

Application: Western Blotting (WB), Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Raptor Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S863 of human Raptor.

Clone: RB24817-24818

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:500. IHC-P: 1:100. DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-RAPTOR (ABIN389879)

Cully, Genevet, Warne, Treins, Liu, Bastien, Baum, Tapon, Leevers, Downward: "A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1." dans: Molecular and cellular biology, Vol. 30, Issue 2, pp. 481-95, (2009) (PubMed).

Détails sur RAPTOR

Antigène: RAPTOR

Autre désignation: Raptor (RAPTOR Produits)

Synonymes: anticorps KOG1, anticorps Mip1, anticorps 4932417H02Rik, anticorps Rap, anticorps Raptor, anticorps mKIAA1303, anticorps RGD1311784, anticorps regulatory associated protein of MTOR complex 1, anticorps regulatory associated protein of MTOR, complex 1, anticorps RPTOR, anticorps Rptor

Sujet: Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.

Poids moléculaire: 149038

ID gène: 57521

NCBI Accession: NP_065812

UniProt: Q8N122

Pathways: L'effet Warburg