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MECP2 anticorps (pSer80)

MECP2 Reactivité: Humain DB Hôte: Lapin Polyclonal RB27934 unconjugated
N° du produit ABIN389978
  • Antigène Voir toutes MECP2 Anticorps
    MECP2 (Methyl CpG Binding Protein 2 (MECP2))
    Épitope
    • 19
    • 10
    • 9
    • 8
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer80
    Reactivité
    • 101
    • 40
    • 31
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 100
    • 7
    • 1
    Lapin
    Clonalité
    • 101
    • 7
    Polyclonal
    Conjugué
    • 62
    • 10
    • 8
    • 8
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MECP2 est non-conjugé
    Application
    • 80
    • 64
    • 36
    • 30
    • 12
    • 9
    • 8
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Dot Blot (DB)
    Homologie
    Pr, M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This MeCP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S80 of human MeCP2.
    Clone
    RB27934
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MECP2 Anticorps primaire
  • Indications d'application
    DB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Liu, Ni, Sun: "Expression of Phospho-MeCP2s in the Developing Rat Brain and Function of Postnatal MeCP2 in Cerebellar Neural Cell Development." dans: Neuroscience bulletin, Vol. 33, Issue 1, pp. 1-16, (2017) (PubMed).

  • Antigène
    MECP2 (Methyl CpG Binding Protein 2 (MECP2))
    Autre désignation
    MeCP2 (MECP2 Produits)
    Synonymes
    anticorps AUTSX3, anticorps MRX16, anticorps MRX79, anticorps MRXS13, anticorps MRXSL, anticorps PPMX, anticorps RS, anticorps RTS, anticorps RTT, anticorps 1500041B07Rik, anticorps BB130002, anticorps D630021H01Rik, anticorps Mbd5, anticorps WBP10, anticorps wu:fk96a04, anticorps zgc:111857, anticorps methyl-CpG binding protein 2, anticorps methyl CpG binding protein 2, anticorps methyl-CpG binding protein 2 S homeolog, anticorps MECP2, anticorps Mecp2, anticorps mecp2, anticorps mecp2.S
    Sujet
    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
    Poids moléculaire
    52441
    ID gène
    4204
    NCBI Accession
    NP_001104262, NP_004983
    UniProt
    P51608
    Pathways
    Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane
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