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ACE2 anticorps (N-Term)

ACE2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB4811-4812 unconjugated
N° du produit ABIN390045
  • Antigène Voir toutes ACE2 Anticorps
    ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
    Épitope
    • 16
    • 13
    • 12
    • 8
    • 8
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 59-90, N-Term
    Reactivité
    • 132
    • 52
    • 46
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 119
    • 19
    • 6
    Lapin
    Clonalité
    • 109
    • 35
    Polyclonal
    Conjugué
    • 72
    • 15
    • 10
    • 8
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ACE2 est non-conjugé
    Application
    • 112
    • 64
    • 48
    • 35
    • 29
    • 19
    • 17
    • 10
    • 10
    • 10
    • 9
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This ACE2 (SARS Receptor) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-90 amino acids from the N-terminal region of human ACE2 (SARS Receptor).
    Clone
    RB4811-4812
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ACE2 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
    Autre désignation
    ACE2 (SARS Receptor) (ACE2 Produits)
    Synonymes
    anticorps ACE1, anticorps CD143, anticorps DCP, anticorps DCP1, anticorps ICH, anticorps MVCD3, anticorps ACEH, anticorps 2010305L05Rik, anticorps zgc:92514, anticorps angiotensin I converting enzyme, anticorps angiotensin I converting enzyme 2, anticorps angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, anticorps ACE, anticorps ACE2, anticorps Ace2, anticorps ace2
    Sujet
    ACE2 cDNA encodes a deduced 805-amino acid protein containing a potential 17-amino acid N-terminal signal peptide and a putative 22-amino acid C-terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamine residue that may function as a third zinc ligand. ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE converts angiotensin I to angiotensin II, ACE2 converts angiotensin I to angiotensin 1-9, which has 9 amino acids. Angiotensin II is a potent blood vessel constrictor, while angiotensin 1-9 does not impact blood vessels but is cleaved by ACE to a shorter peptide, angiotensin 1-7, which is a blood vessel dilator. Spike (S) proteins of coronaviruses, including the SARS coronavirus, bind with cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of the SARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-transfected but not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viral replication on Vero E6 cells. It has been proposed that ACE2 is a functional receptor for SARS coronavirus.
    Poids moléculaire
    92463
    ID gène
    59272
    NCBI Accession
    NP_068576
    UniProt
    Q9BYF1
    Pathways
    ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
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