This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This ABCB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ABCB5.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid freeze-thaw cycles.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Date de péremption
6 months
Ksander, Kolovou, Wilson, Saab, Guo, Ma, McGuire, Gregory, Vincent, Perez, Cruz-Guilloty, Kao, Call, Tucker, Zhan, Murphy, Lathrop, Alt, Mortensen, Lin, Zieske, Frank, Frank: "ABCB5 is a limbal stem cell gene required for corneal development and repair." dans: Nature, Vol. 511, Issue 7509, pp. 353-7, (2014) (PubMed).
Freeman, Gray, Millward, Pearce, Ziman: "Evaluation of a multi-marker immunomagnetic enrichment assay for the quantification of circulating melanoma cells." dans: Journal of translational medicine, Vol. 10, pp. 192, (2013) (PubMed).
Luo, Ellis, Dallaglio, Takeda, Robinson, Robinson, Liu, Lewis, McCarter, Gonzalez, Norris, Roop, Spritz, Ahn, Fujita: "Side population cells from human melanoma tumors reveal diverse mechanisms for chemoresistance." dans: The Journal of investigative dermatology, Vol. 132, Issue 10, pp. 2440-50, (2012) (PubMed).
Lai, Schwartz, Hsu: "CD133+ melanoma subpopulations contribute to perivascular niche morphogenesis and tumorigenicity through vasculogenic mimicry." dans: Cancer research, Vol. 72, Issue 19, pp. 5111-8, (2012) (PubMed).
Wilson, Schatton, Zhan, Gasser, Ma, Saab, Schanche, Waaga-Gasser, Gold, Huang, Murphy, Frank, Frank: "ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients." dans: Cancer research, Vol. 71, Issue 15, pp. 5307-16, (2011) (PubMed).
Ramgolam, Lauriol, Lalou, Lauden, Michel, de la Grange, Khatib, Aoudjit, Charron, Alcaide-Loridan, Al-Daccak: "Melanoma spheroids grown under neural crest cell conditions are highly plastic migratory/invasive tumor cells endowed with immunomodulator function." dans: PLoS ONE, Vol. 6, Issue 4, pp. e18784, (2011) (PubMed).
Antigène
ABCB5
(ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))
anticorps ABCB5alpha, anticorps ABCB5beta, anticorps EST422562, anticorps 9230106F14Rik, anticorps RGD1566342, anticorps ABCB5, anticorps mdr1, anticorps im:7158730, anticorps wu:fc18f02, anticorps wu:fi81f06, anticorps ATP binding cassette subfamily B member 5, anticorps ATP-binding cassette, sub-family B (MDR/TAP), member 5, anticorps ATP-binding cassette sub-family B member 5, anticorps ABCB5, anticorps Abcb5, anticorps abcb5, anticorps TGME49_249820, anticorps PAAG_04387, anticorps VDBG_00160, anticorps VDBG_02292
Sujet
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules.