BIRC3 anticorps (N-Term)

N° du produit ABIN390069

Cité dans 2 publications. Cet anticorps anti-BIRC3 Polyclonal Lapin (Clone RB2213) (ABIN390069) détecte spécifiquement BIRC3 dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour BIRC3 anticorps (N-Term) (ABIN390069)

Antigène: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIRC3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB2213

Détail du produit anti-BIRC3 anticorps

Épitope: AA 101-131, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This cIAP2 (BIRC3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human cIAP2 (BIRC3).

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-BIRC3 (ABIN390069)

Chen, Xie, Gu, Cai, Wang, Xie, Dong, He, Zhong, Lin, Huang: "Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation." dans: Scientific reports, Vol. 5, pp. 8293, (2015) (PubMed).

Sun, Liu, Zou, Lan, Sun, Wang, Zhao, Jiang, Liu: "Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer." dans: Journal of bioenergetics and biomembranes, (2015) (PubMed).

Détails sur BIRC3

Antigène: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Autre désignation: cIAP2 (BIRC3)

Sujet: BIRC3 is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain.

Poids moléculaire: 68372

ID gène: 330

NCBI Accession: NP_001156, NP_892007

UniProt: Q13489

Pathways: Apoptose, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades