MAGEA3 anticorps (C-Term)

N° du produit ABIN390107

Détail du produit anti-MAGEA3 anticorps

Antigène: MAGEA3 (Melanoma Antigen Family A, 3 (MAGEA3))

Épitope: AA 283-314, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAGEA3 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This MAGEA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-314 amino acids from the C-terminal region of human MAGEA3.

Clone: RB2084

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-MAGEA3 (ABIN390107)

Curioni-Fontecedro, Knights, Tinguely, Nuber, Schneider, Thomson, von Boehmer, Bossart, Pahlich, Gehring, Moch, Renner, Knuth, Zippelius: "MAGE-C1/CT7 is the dominant cancer-testis antigen targeted by humoral immune responses in patients with multiple myeloma." dans: Leukemia, Vol. 22, Issue 8, pp. 1646-8, (2008) (PubMed).

Dubovsky, Albertini, McNeel: "MAD-CT-2 identified as a novel melanoma cancer-testis antigen using phage immunoblot analysis." dans: Journal of immunotherapy (Hagerstown, Md. : 1997), Vol. 30, Issue 7, pp. 675-83, (2007) (PubMed).

Kondo, Zhu, Asa, Ezzat: "The cancer/testis antigen melanoma-associated antigen-A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 16, pp. 4713-20, (2007) (PubMed).

Détails sur MAGEA3

Antigène: MAGEA3 (Melanoma Antigen Family A, 3 (MAGEA3))

Autre désignation: MAGEA3 (MAGEA3 Produits)

Synonymes: anticorps CT1.3, anticorps HIP8, anticorps HYPD, anticorps MAGE3, anticorps MAGEA6, anticorps Mage-a3, anticorps MAGEA3, anticorps MAGE family member A3, anticorps melanoma antigen, family A, 3, anticorps melanoma antigen family A, 3, anticorps MAGEA3, anticorps Magea3

Sujet: MAGEA3 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80 % sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.

Poids moléculaire: 34747

ID gène: 4102

NCBI Accession: NP_005353

UniProt: P43357