MLLT10 anticorps (C-Term)

N° du produit ABIN390125

Détail du produit anti-MLLT10 anticorps

Antigène: MLLT10 (Protein AF-10 (MLLT10))

Épitope: AA 998-1027, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLLT10 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This MLLT10 (AF10) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 998-1027 amino acids from the C-terminal region of human MLLT10 (AF10).

Clone: RB1930

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur MLLT10

Antigène: MLLT10 (Protein AF-10 (MLLT10))

Autre désignation: MLLT10 (AF10) (MLLT10 Produits)

Synonymes: anticorps AF10, anticorps Af10, anticorps B130021D15Rik, anticorps D630001B22Rik, anticorps mKIAA4140, anticorps MLLT10, histone lysine methyltransferase DOT1L cofactor, anticorps myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10, anticorps MLLT10, anticorps Mllt10

Sujet: Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t(10,11)(p12,q23) translocations. In an analysis of two leukemia patients, the in t(10,11)(p12,q23) translocation fuses MLL1, a SET domain containg histone methyltransferase, to the MLLT10 gene. The MLLT10 gene encodes a predicted 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain. The MLLT10 gene is one of the few MLL partner genes to be independently rearranged with a third gene in leukemia, the CALM gene in the t(10,11)(p12,q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 consistently retain the leucine zipper motif of MLLT10. The leucine zipper interacts with GAS41, a protein previously identified as the product of an amplified gene in a glioblastoma. GAS41 interacts with integrase interactor-1 (INI1), a component of the SWI/SNF complex, which acts to remodel chromatin and to modulate transcription. Retention of the leucine zipper in the MLL and CALM fusions suggested that a key feature of these chimeric proteins may be their ability to interfere in normal gene regulation through interaction with the adenosine triphosphate-dependent chromatin remodeling complexes.

Poids moléculaire: 113320

ID gène: 8028

NCBI Accession: NP_001182555, NP_001182556, NP_001182557, NP_001182559, NP_004632

UniProt: P55197