OAS3 anticorps (C-Term)

N° du produit ABIN390166

Détail du produit anti-OAS3 anticorps

Antigène: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Épitope: AA 1056-1087, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OAS3 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This OAS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1056-1087 amino acids from the C-terminal region of human OAS3.

Clone: RB1945

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-OAS3 (ABIN390166)

Ibsen, Gad, Thavachelvam, Boesen, Desprès, Hartmann: "The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation." dans: Journal of virology, Vol. 88, Issue 24, pp. 14222-31, (2014) (PubMed).

Détails sur OAS3

Antigène: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Autre désignation: OAS3 (OAS3 Produits)

Synonymes: anticorps p100, anticorps Oasl10, anticorps 2'-5'-oligoadenylate synthetase 3, anticorps 2'-5' oligoadenylate synthetase 3, anticorps OAS3, anticorps Oas3

Sujet: OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.

Poids moléculaire: 121170

ID gène: 4940

NCBI Accession: NP_006178

UniProt: Q9Y6K5

Pathways: Hepatitis C