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WISP1 anticorps (AA 171-200)

WISP1 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB2115-2116 unconjugated
N° du produit ABIN390187
  • Antigène Voir toutes WISP1 Anticorps
    WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
    Épitope
    • 15
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 171-200
    Reactivité
    • 40
    • 26
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 54
    • 5
    • 1
    • 1
    Lapin
    Clonalité
    • 57
    • 4
    Polyclonal
    Conjugué
    • 26
    • 9
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp WISP1 est non-conjugé
    Application
    • 35
    • 21
    • 20
    • 13
    • 13
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This WISP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 amino acids from the Central region of human WISP1.
    Clone
    RB2115-2116
    Isotype
    Ig Fraction
    Top Product
    Discover our top product WISP1 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Ji, Jia, Jia, Ji, Hargest, Jiang: "WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-? pathways." dans: British journal of cancer, Vol. 113, Issue 6, pp. 921-33, (2015) (PubMed).

  • Antigène
    WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
    Autre désignation
    WISP1 (WISP1 Produits)
    Synonymes
    anticorps CCN4, anticorps WISP1c, anticorps WISP1i, anticorps WISP1tc, anticorps WISP-1, anticorps WISP1, anticorps si:ch211-38f10.2, anticorps AW146261, anticorps Elm1, anticorps zgc:172276, anticorps WNT1 inducible signaling pathway protein 1, anticorps WNT1 inducible signaling pathway protein 1a, anticorps WNT1-inducible-signaling pathway protein 1-like, anticorps WNT1 inducible signaling pathway protein 1b, anticorps WISP1, anticorps wisp1a, anticorps Wisp1, anticorps LOC100627044, anticorps wisp1b
    Sujet
    Wisp1 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. Wisp1 may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83 % identical to the mouse protein at the amino acid level.
    Poids moléculaire
    40331
    ID gène
    8840
    NCBI Accession
    NP_001191798, NP_001191799, NP_003873, NP_543028
    UniProt
    O95388
    Pathways
    Signalisation WNT, Growth Factor Binding
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