WISP2 anticorps (AA 87-116)

N° du produit ABIN390188

Détail du produit anti-WISP2 anticorps

Antigène: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Épitope: AA 87-116

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WISP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This WISP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the Central region of human WISP2.

Clone: RB2114

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-WISP2 (ABIN390188)

Ji, Jia, Jia, Ji, Hargest, Jiang: "WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-? pathways." dans: British journal of cancer, Vol. 113, Issue 6, pp. 921-33, (2015) (PubMed).

Détails sur WISP2

Antigène: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Autre désignation: WISP2 (WISP2 Produits)

Synonymes: anticorps MGC84196, anticorps WISP2, anticorps ccn5, anticorps CCN5, anticorps CT58, anticorps CTGF-L, anticorps Ccn5, anticorps Crgr4, anticorps Ctgfl, anticorps Rcop1, anticorps WNT1 inducible signaling pathway protein 2, anticorps WNT1 inducible signaling pathway protein 2 S homeolog, anticorps WISP2, anticorps wisp2.S, anticorps wisp2, anticorps Wisp2

Sujet: Wisp2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. Wisp2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72 % identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Poids moléculaire: 26825

ID gène: 8839

NCBI Accession: NP_003872

UniProt: O76076

Pathways: Signalisation WNT, Growth Factor Binding