SETD8 anticorps (AA 220-249)

N° du produit ABIN390472

Détail du produit anti-SETD8 anticorps

Antigène: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Épitope: AA 220-249

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETD8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Homologie: B

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This SETD8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-249 amino acids from the Central region of human SETD8.

Clone: RB18964

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur SETD8

Antigène: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Autre désignation: SETD8 (SETD8 Produits)

Synonymes: anticorps KMT5A, anticorps PR-Set7, anticorps SET07, anticorps SET8, anticorps 2410195B05Rik, anticorps AA617402, anticorps AW536475, anticorps PR-SET7, anticorps setd8b, anticorps wu:fc23f12, anticorps zgc:171649, anticorps Pr-set7, anticorps RGD1305893, anticorps Setd8, anticorps kmt5a, anticorps kmt5a-a, anticorps setd8, anticorps setd8-a, anticorps set8a, anticorps setd8a, anticorps wu:fj33f02, anticorps zgc:153719, anticorps lysine methyltransferase 5A, anticorps lysine methyltransferase 5Ab, anticorps lysine methyltransferase 5A S homeolog, anticorps lysine methyltransferase 5Aa, anticorps KMT5A, anticorps Kmt5a, anticorps kmt5ab, anticorps kmt5a.S, anticorps kmt5aa

Sujet: SETD8 is a histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It is required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. It is also involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.

Poids moléculaire: 42890

ID gène: 387893

NCBI Accession: NP_065115

UniProt: Q9NQR1