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MTMR4 anticorps (C-Term)

MTMR4 Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal RB0716 unconjugated
N° du produit ABIN390777
  • Antigène Voir toutes MTMR4 Anticorps
    MTMR4 (Myotubularin Related Protein 4 (MTMR4))
    Épitope
    • 7
    • 7
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1155-1187, C-Term
    Reactivité
    • 37
    • 11
    • 3
    Humain, Souris
    Hôte
    • 36
    • 1
    Lapin
    Clonalité
    • 37
    Polyclonal
    Conjugué
    • 15
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MTMR4 est non-conjugé
    Application
    • 26
    • 23
    • 10
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This MTMR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1155-1187 amino acids from the C-terminal region of human MTMR4.
    Clone
    RB0716
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Yu, He, Chen, Hao, Yang, Wang, Pan, Tang: "Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins." dans: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 79-88, (2013) (PubMed).

    Yu, Pan, Qin, Chen, Xu, Chen, Tang: "MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes." dans: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8454-62, (2010) (PubMed).

    Plant, Correa, Goldenberg, Bain, Batt: "The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4." dans: The Biochemical journal, Vol. 419, Issue 1, pp. 57-63, (2009) (PubMed).

  • Antigène
    MTMR4 (Myotubularin Related Protein 4 (MTMR4))
    Autre désignation
    MTMR4 (MTMR4 Produits)
    Synonymes
    anticorps zfyve11, anticorps fyve-dsp2, anticorps FYVE-DSP2, anticorps ZFYVE11, anticorps AA596759, anticorps ESTM44, anticorps mKIAA0647, anticorps myotubularin related protein 4, anticorps myotubularin related protein 4 L homeolog, anticorps Mtmr4, anticorps MTMR4, anticorps mtmr4, anticorps mtmr4.L
    Sujet
    MTMR, a member of the myotubularin family, encodes an intracellular protein of 1,195 amino acids, and shares approximately 47 % sequence identity with MTMR3, spiking to over 70 % identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.
    Poids moléculaire
    133353
    ID gène
    9110
    NCBI Accession
    NP_004678
    UniProt
    Q9NYA4
    Pathways
    Inositol Metabolic Process
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