MKNK2 anticorps (N-Term)
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- Antigène Voir toutes MKNK2 Anticorps
- MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
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Épitope
- AA 70-100, N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MKNK2 est non-conjugé
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Application
- Western Blotting (WB)
- Homologie
- M, Rat
- Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogène
- This MNK2 (MKNK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-100 amino acids from the N-terminal region of human MNK2 (MKNK2).
- Clone
- RB5445
- Isotype
- Ig Fraction
- Top Product
- Discover our top product MKNK2 Anticorps primaire
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- Indications d'application
- WB: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Date de péremption
- 6 months
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- Antigène
- MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
- Autre désignation
- MNK2 (MKNK2) (MKNK2 Produits)
- Synonymes
- anticorps GPRK7, anticorps MNK2, anticorps gprk7, anticorps mnk2, anticorps 2010016G11Rik, anticorps Gprk7, anticorps Mnk2, anticorps mknk2, anticorps wu:fb37e05, anticorps wz5090, anticorps fi34c11, anticorps wu:fi34c11, anticorps wu:fi41e12, anticorps zgc:55587, anticorps MAP kinase interacting serine/threonine kinase 2, anticorps MAP kinase-interacting serine/threonine kinase 2, anticorps MAP kinase interacting serine/threonine kinase 2b, anticorps MAP kinase interacting serine/threonine kinase 2 L homeolog, anticorps MAP kinase interacting serine/threonine kinase 2a, anticorps MKNK2, anticorps mknk2, anticorps Mknk2, anticorps mknk2b, anticorps mknk2.L, anticorps mknk2a
- Sujet
- MAP kinase-interacting kinase 1 (Mnk1) and Mnk2, members of the Ser/Thr protein kinase family, bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2. Erk and p38 phosphorylate MNK1 and Mnk2, which stimulates their in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E). Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. This ubiquitiously expressed protein appears to regulate transcription by phosphorylating eIF-4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94 % identical) and human Mnk1 (71 % identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta. Mnk2 has also been shown to interact with the C-terminal regions of eIF-4G1 and eIF-4G2.
- Poids moléculaire
- 51875
- ID gène
- 2872
- NCBI Accession
- NP_060042, NP_951009
- UniProt
- Q9HBH9
- Pathways
- Signalisation MAPK
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