Deoxyguanosine Kinase anticorps (N-Term)

N° du produit ABIN391122

Détail du produit anti-Deoxyguanosine Kinase anticorps

Antigène: Deoxyguanosine Kinase (DGUOK)

Épitope: AA 1-30, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Deoxyguanosine Kinase est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This Deoxyguanosine Kinase (DGUOK) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human Deoxyguanosine Kinase (DGUOK).

Clone: RB5277

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur Deoxyguanosine Kinase

Antigène: Deoxyguanosine Kinase (DGUOK)

Abstract: DGUOK Produits

Synonymes: anticorps DGUOK, anticorps zgc:86625, anticorps dgk, anticorps DDBDRAFT_0218264, anticorps DDBDRAFT_0233982, anticorps DDB_0218264, anticorps DDB_0233982, anticorps MTDPS3, anticorps dGK, anticorps dGK1, anticorps dGK2, anticorps dGK3, anticorps deoxyguanosine kinase, anticorps deoxyguanosine kinase L homeolog, anticorps DGUOK, anticorps dguok, anticorps dguok.L, anticorps dgk, anticorps Ccan_04750, anticorps Dguok

Sujet: Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.

Poids moléculaire: 32056

ID gène: 1716

NCBI Accession: NP_550438, NP_550440

UniProt: Q16854

Pathways: Ribonucleoside Biosynthetic Process