CERK anticorps (C-Term)

N° du produit ABIN391126

Détail du produit anti-CERK anticorps

Antigène: CERK (Ceramide Kinase (CERK))

Épitope: AA 487-516, C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CERK est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This CERK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-516 amino acids from the C-terminal region of human CERK.

Clone: RB5271

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-CERK (ABIN391126)

Murakami, Ito, Hagiwara, Yoshida, Sobue, Ichihara, Takagi, Kojima, Tanaka, Tamiya-Koizumi, Kyogashima, Suzuki, Banno, Nozawa, Murate: "ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI." dans: Journal of neurochemistry, Vol. 112, Issue 2, pp. 511-20, (2010) (PubMed).

Yang, Gagarin, St Laurent, Hammell, Toma, Hu, Iwasa, McCaffrey: "Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 8, pp. 1213-9, (2009) (PubMed).

Hinkovska-Galcheva, Clark, VanWay, Huang, Hiraoka, Abe, Borofsky, Kunkel, Shanley, Shayman, Lanni, Petty, Boxer: "Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells." dans: Journal of lipid research, Vol. 49, Issue 3, pp. 531-42, (2008) (PubMed).

Détails sur CERK

Antigène: CERK (Ceramide Kinase (CERK))

Autre désignation: CERK (CERK Produits)

Synonymes: anticorps AI848610, anticorps D330016D08Rik, anticorps mKIAA1646, anticorps LK4, anticorps dA59H18.2, anticorps dA59H18.3, anticorps hCERK, anticorps CERK, anticorps si:ch211-162i19.1, anticorps MGC81777, anticorps CG16708, anticorps DCERK, anticorps Dcerk, anticorps Dmel\\CG16708, anticorps dcerk, anticorps ceramide kinase, anticorps ceramide kinase S homeolog, anticorps Ceramide kinase, anticorps Cerk, anticorps CERK, anticorps cerk, anticorps cerk.S, anticorps CpipJ_CPIJ003342, anticorps LOAG_11245, anticorps LOC5579301, anticorps Bm1_50005

Sujet: Ceramide kinases convert the sphingolipid metabolite ceramide into ceramide-1-phosphate, both key mediators of cellular apoptosis and survival. Ceramide metabolism plays an essential role in the viability of neuronal cells, the membranes of which are particularly rich in sphingolipids. CERK catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This enzyme acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8 dihydroceramide), and to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. High level expression is noted in heart, brain, skeletal muscle, kidney and liver, moderate expression in peripheral blood leukocytes and thymus, and low expression in spleen, small intestine, placenta and lung.

ID gène: 64781

NCBI Accession: NP_073603

UniProt: Q8TCT0