LRRK2 anticorps (AA 930-961)

N° du produit ABIN391148

Détail du produit anti-LRRK2 anticorps

Antigène: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Épitope: AA 930-961

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRRK2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PARK8(LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 930-961 amino acids from human PARK8(LRRK2).

Clone: RB07209

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-LRRK2 (ABIN391148)

Huang, Song, Murphy, Holton, Lashley, Revesz, Gai, Halliday: "LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions." dans: Acta neuropathologica, Vol. 116, Issue 6, pp. 639-46, (2009) (PubMed).

Biskup, Moore, Rea, Lorenz-Deperieux, Coombes, Dawson, Dawson, West: "Dynamic and redundant regulation of LRRK2 and LRRK1 expression." dans: BMC neuroscience, Vol. 8, pp. 102, (2008) (PubMed).

Détails sur LRRK2

Antigène: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Autre désignation: PARK8 (LRRK2) (LRRK2 Produits)

Synonymes: anticorps LRRK2, anticorps AURA17, anticorps DARDARIN, anticorps PARK8, anticorps RIPK7, anticorps ROCO2, anticorps 4921513O20Rik, anticorps 9330188B09Rik, anticorps AW561911, anticorps D630001M17Rik, anticorps Gm927, anticorps cI-46, anticorps leucine-rich repeat kinase 2, anticorps leucine rich repeat kinase 2, anticorps lrrk2, anticorps LRRK2, anticorps Lrrk2

Sujet: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.

Poids moléculaire: 286103

ID gène: 120892

NCBI Accession: NP_940980

UniProt: Q5S007

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development