STRADB anticorps (C-Term)

N° du produit ABIN391172

Détail du produit anti-STRADB anticorps

Antigène: STRADB (STE20-Related Kinase Adaptor beta (STRADB))

Épitope: AA 274-303, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STRADB est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This ALS2CR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-303 amino acids from the C-terminal region of human ALS2CR2.

Clone: RB15723

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur STRADB

Antigène: STRADB (STE20-Related Kinase Adaptor beta (STRADB))

Autre désignation: ALS2CR2 (STRADB Produits)

Synonymes: anticorps Als2cr2, anticorps RGD1559449, anticorps als2cr2, anticorps MGC82468, anticorps STRADB, anticorps ALS2CR2, anticorps AA792893, anticorps B830008M19, anticorps D1Ucla2, anticorps ILPIP, anticorps ILPIPA, anticorps PRO1038, anticorps Papk, anticorps Syradb, anticorps CALS-21, anticorps PAPK, anticorps STE20-related kinase adaptor beta, anticorps STE20-related kinase adaptor beta L homeolog, anticorps Stradb, anticorps STRADB, anticorps stradb.L

Sujet: ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2.

Poids moléculaire: 47026

ID gène: 55437

NCBI Accession: NP_001193793, NP_061041

UniProt: Q9C0K7

Pathways: AMPK Signaling