STRADA anticorps (N-Term)

N° du produit ABIN391217

Détail du produit anti-STRADA anticorps

Antigène: STRADA (STE20-Related Kinase Adaptor alpha (STRADA))

Épitope: AA 12-41, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STRADA est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This LYK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-41 amino acids from the N-terminal region of human LYK5.

Clone: RB8539

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:25. WB: 1:1000. WB: 1:1000. WB: 1:2000. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur STRADA

Antigène: STRADA (STE20-Related Kinase Adaptor alpha (STRADA))

Autre désignation: LYK5 (STRADA Produits)

Synonymes: anticorps fj99g05, anticorps zgc:56109, anticorps wu:fj99g05, anticorps lyk5, anticorps LYK5, anticorps NY-BR-96, anticorps PMSE, anticorps STRAD, anticorps Stlk, anticorps Lyk5, anticorps 2610019A05Rik, anticorps 6030402H20Rik, anticorps AI480680, anticorps E130112C09Rik, anticorps STE20-related kinase adaptor alpha, anticorps ste20-related kinase adaptor alpha, anticorps STRADA, anticorps strada, anticorps Strada

Sujet: LYK5, also STE20-related Adaptor Protein (STRAD) are members of STE-20 like kinase family that are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.

Poids moléculaire: 48369

ID gène: 92335

NCBI Accession: NP_001003786, NP_001003787, NP_001003788, NP_001159441, NP_001159442, NP_699166

UniProt: Q7RTN6

Pathways: AMPK Signaling