DCLK1 anticorps (N-Term)

N° du produit ABIN391323

Détail du produit anti-DCLK1 anticorps

Antigène: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Épitope: AA 1-30, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCLK1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This DCAMKL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DCAMKL1.

Clone: RB3059

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-DCLK1 (ABIN391323)

Sala, Matthews, Speer, Torashima, Barthel, Grikscheit: "A multicellular approach forms a significant amount of tissue-engineered small intestine in the mouse." dans: Tissue engineering. Part A, Vol. 17, Issue 13-14, pp. 1841-50, (2011) (PubMed).

Tu, Quante, Bhagat, Takaishi, Cui, Yang, Muthuplani, Shibata, Fox, Pritchard, Wang: "IFN-? inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis." dans: Cancer research, Vol. 71, Issue 12, pp. 4247-59, (2011) (PubMed).

Shibata, Takaishi, Muthupalani, Pritchard, Whary, Rogers, Fox, Betz, Kaestner, Karin, Wang: "Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia." dans: Gastroenterology, Vol. 138, Issue 3, pp. 1022-34.e1-10, (2010) (PubMed).

Jin, Ramanathan, Quante, Baik, Yang, Wang, Tu, Gordon, Pritchard, Varro, Shulkes, Wang: "Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice." dans: The Journal of clinical investigation, Vol. 119, Issue 9, pp. 2691-701, (2009) (PubMed).

Gyamfi, Tanaka, He, Klaassen, Wan: "Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice." dans: Toxicology and applied pharmacology, Vol. 234, Issue 2, pp. 166-78, (2009) (PubMed).

Détails sur DCLK1

Antigène: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Autre désignation: DCAMKL1 (DCLK1 Produits)

Synonymes: anticorps DCLK1, anticorps DCAMKL1, anticorps dcamkl1, anticorps dclk1, anticorps wu:fc51f11, anticorps zgc:153709, anticorps MGC145348, anticorps CL1, anticorps CLICK1, anticorps DCDC3A, anticorps DCLK, anticorps 1700113D08Rik, anticorps 2810480F11Rik, anticorps AI836758, anticorps Click-I, anticorps Cpg16, anticorps Dcamkl1, anticorps Dcl, anticorps Dclk, anticorps mKIAA0369, anticorps Ania4, anticorps doublecortin like kinase 1, anticorps doublecortin-like kinase 1a, anticorps serine/threonine-protein kinase DCLK1, anticorps doublecortin-like kinase 2, anticorps doublecortin-like kinase 1, anticorps DCLK1, anticorps dclk1a, anticorps LOC587664, anticorps dclk2, anticorps LOC100539645, anticorps Dclk1

Sujet: Doublecortin-like kinase (DCAMKL1)(Ser/Thr protein kinase family) is essential for proper neurogenesis, neuronal migration, and axonal wiring. DCAMKL1 is involved in a calcium-signaling pathway controling neuronal migration in the developing brain, and participates in functions of the mature nervous system. DCAMKL1 protein shares high homology with doublecortin (DCX). DCLK, but not DCX, is highly expressed in regions of active neurogenesis in the neocortex and cerebellum. DCAMKL1 controls mitotic division by regulating spindle formation and also determines the fate of neural progenitors during cortical neurogenesis.

Poids moléculaire: 82224

ID gène: 9201

NCBI Accession: NP_001182344, NP_001182345, NP_004725

UniProt: O15075