DCLK1 anticorps (AA 690-720)

N° du produit ABIN391324

Détail du produit anti-DCLK1 anticorps

Antigène: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Épitope: AA 690-720

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCLK1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DCAMKL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 690-720 amino acids of human DCAMKL1.

Clone: RB3161

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. WB: 1:1000. WB: 1:8000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-DCLK1 (ABIN391324)

Kawamura, Takemoto, Nishimoto, Ueno, Hosoyama, Shirasawa, Tanaka, Kugimiya, Harada, Hamano: "Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells." dans: Oncology reports, Vol. 38, Issue 5, pp. 3238-3244, (2018) (PubMed).

Ushiama, Ishimaru, Narukawa, Yoshioka, Kozuka, Watanabe, Tsunoda, Osakabe, Asakura, Masuzaki, Abe: "Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice." dans: EBioMedicine, Vol. 8, pp. 60-71, (2017) (PubMed).

Gao, Wang, Xu, Wen, Liu, An: "DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer." dans: Journal of cancer research and clinical oncology, Vol. 142, Issue 10, pp. 2131-40, (2017) (PubMed).

Leppänen, Helminen, Huhta, Kauppila, Miinalainen, Ronkainen, Saarnio, Lehenkari, Karttunen: "Doublecortin-like kinase 1-positive enterocyte - a new cell type in human intestine." dans: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 124, Issue 11, pp. 958-965, (2017) (PubMed).

Schellnegger, Quante, Rospleszcz, Schernhammer, Höhl, Tobiasch, Pastula, Brandtner, Abrams, Strauch, Schmid, Vieth, Wang, Quante: "Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma." dans: Cancer prevention research (Philadelphia, Pa.), Vol. 10, Issue 1, pp. 55-66, (2017) (PubMed).

Nakata, Shimizu, Nagata, Ito, Fujii, Suzuki, Kawamoto, Ishibashi, Kuno, Anzai, Murano, Mizutani, Oshima, Tsuchiya, Nakamura, Hozumi, Watanabe, Okamoto: "Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine." dans: Data in brief, Vol. 10, pp. 551-556, (2017) (PubMed).

Gross, Balderes, Liu, Asfaha, Gu, Wang, Sussel: "Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential." dans: American journal of physiology. Gastrointestinal and liver physiology, pp. ajpgi.00244.2015, (2015) (PubMed).

Shimizu, Okamoto, Ito, Fujii, Nakata, Suzuki, Murano, Mizutani, Tsuchiya, Nakamura, Hozumi, Watanabe: "Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine." dans: PeerJ, Vol. 2, pp. e370, (2014) (PubMed).

Gonzalez, Williamson, Piedrahita, Blikslager, Magness: "Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration." dans: PLoS ONE, Vol. 8, Issue 6, pp. e66465, (2013) (PubMed).

Trivedi, Wiber, El-Zimaity, Brubaker: "Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer." dans: American journal of physiology. Gastrointestinal and liver physiology, Vol. 302, Issue 8, pp. G840-9, (2012) (PubMed).

Yu, Chen, Zhang, Li, Xu, Wang, Ai, Liu: "Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity." dans: PLoS ONE, Vol. 7, Issue 2, pp. e32492, (2012) (PubMed).

Gerbe, van Es, Makrini, Brulin, Mellitzer, Robine, Romagnolo, Shroyer, Bourgaux, Pignodel, Clevers, Jay: "Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium." dans: The Journal of cell biology, Vol. 192, Issue 5, pp. 767-80, (2011) (PubMed).

Gerbe, Brulin, Makrini, Legraverend, Jay: "DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium." dans: Gastroenterology, Vol. 137, Issue 6, pp. 2179-80; author reply 2180-1, (2009) (PubMed).

Dekaney, Gulati, Garrison, Helmrath, Henning: "Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice." dans: American journal of physiology. Gastrointestinal and liver physiology, Vol. 297, Issue 3, pp. G461-70, (2009) (PubMed).

May, Riehl, Hunt, Sureban, Anant, Houchen et al.: "Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple ..." dans: Stem cells (Dayton, Ohio), Vol. 26, Issue 3, pp. 630-7, (2008) (PubMed).

Détails sur DCLK1

Antigène: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Autre désignation: DCAMKL1 (DCLK1 Produits)

Synonymes: anticorps DCLK1, anticorps DCAMKL1, anticorps dcamkl1, anticorps dclk1, anticorps wu:fc51f11, anticorps zgc:153709, anticorps MGC145348, anticorps CL1, anticorps CLICK1, anticorps DCDC3A, anticorps DCLK, anticorps 1700113D08Rik, anticorps 2810480F11Rik, anticorps AI836758, anticorps Click-I, anticorps Cpg16, anticorps Dcamkl1, anticorps Dcl, anticorps Dclk, anticorps mKIAA0369, anticorps Ania4, anticorps doublecortin like kinase 1, anticorps doublecortin-like kinase 1a, anticorps serine/threonine-protein kinase DCLK1, anticorps doublecortin-like kinase 2, anticorps doublecortin-like kinase 1, anticorps DCLK1, anticorps dclk1a, anticorps LOC587664, anticorps dclk2, anticorps LOC100539645, anticorps Dclk1

Sujet: Doublecortin-like kinase (DCAMKL1)(Ser/Thr protein kinase family) is essential for proper neurogenesis, neuronal migration, and axonal wiring. DCAMKL1 is involved in a calcium-signaling pathway controling neuronal migration in the developing brain, and participates in functions of the mature nervous system. DCAMKL1 protein shares high homology with doublecortin (DCX). DCLK, but not DCX, is highly expressed in regions of active neurogenesis in the neocortex and cerebellum. DCAMKL1 controls mitotic division by regulating spindle formation and also determines the fate of neural progenitors during cortical neurogenesis.

Poids moléculaire: 82224

ID gène: 9201

NCBI Accession: NP_001182344, NP_001182345, NP_004725

UniProt: O15075