MAPK10 anticorps (N-Term)

N° du produit ABIN391727

Détail du produit anti-MAPK10 anticorps

Antigène: MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Épitope: AA 1-30, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPK10 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This MAPK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MAPK10.

Clone: RB01017

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-MAPK10 (ABIN391727)

Kuo, Hu, Hsu, Tung, Wang, Tsai, Yen, Liao: "Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin." dans: Molecular biology of the cell, Vol. 19, Issue 10, pp. 4201-12, (2008) (PubMed).

Détails sur MAPK10

Antigène: MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Autre désignation: JNK3 (MAPK10 Produits)

Synonymes: anticorps MAPK10, anticorps zgc:123234, anticorps DKFZp459H0638, anticorps Jnk3, anticorps SAPKC, anticorps SAPb, anticorps Serk2, anticorps JNK3, anticorps JNK3A, anticorps PRKM10, anticorps SAPK1b, anticorps p493F12, anticorps p54bSAPK, anticorps C230008H04Rik, anticorps JNK3B1, anticorps JNK3B2, anticorps SAPK(beta), anticorps ATMPK10, anticorps MAP kinase 10, anticorps mitogen-activated protein kinase 8 S homeolog, anticorps mitogen-activated protein kinase 10, anticorps mitogen activated protein kinase 10, anticorps MAP kinase 10, anticorps mapk8.S, anticorps MAPK10, anticorps mapk10, anticorps Mapk10, anticorps MPK10

Sujet: JNK3 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.

Poids moléculaire: 52585

ID gène: 5602

NCBI Accession: NP_002744, NP_620446, NP_620447, NP_620448

UniProt: P53779

Pathways: Signalisation MAPK, Signalisation WNT, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades