This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This MUSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-65 amino acids from the N-terminal region of human MUSK.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Chevessier, Faraut, Ravel-Chapuis, Richard, Gaudon, Bauché, Prioleau, Herbst, Goillot, Ioos, Azulay, Attarian, Leroy, Fournier, Legay, Schaeffer, Koenig, Fardeau, Eymard, Pouget, Hantaï: "[Pathophysiological characterization of congenital myasthenic syndromes: the example of mutations in the MUSK gene]." dans: Journal de la Société de biologie, Vol. 199, Issue 1, pp. 61-77, (2005) (PubMed).
Chevessier, Faraut, Ravel-Chapuis, Richard, Gaudon, Bauché, Prioleau, Herbst, Goillot, Ioos, Azulay, Attarian, Leroy, Fournier, Legay, Schaeffer, Koenig, Fardeau, Eymard, Pouget, Hantaï: "MUSK, a new target for mutations causing congenital myasthenic syndrome." dans: Human molecular genetics, Vol. 13, Issue 24, pp. 3229-40, (2004) (PubMed).
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).