BACE1 anticorps (N-Term)

N° du produit ABIN392201

Détail du produit anti-BACE1 anticorps

Antigène: BACE1 (Beta-secretase 1 (BACE1))

Épitope: AA 38-70, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BACE1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This BACE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-70 amino acids from the N-terminal region of human BACE1.

Clone: RB16874

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-BACE1 (ABIN392201)

Lu, Cui, Li, Wang, Zhou, Yang, Chen, Zhao, Pei: "An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity." dans: PLoS ONE, Vol. 11, Issue 11, pp. e0166415, (2017) (PubMed).

Lu, Li, Wang, Pei: "Dopamine D2 receptor and β-arrestin 2 mediate Amyloid-β elevation induced by anti-parkinson's disease drugs, levodopa and piribedil, in neuronal cells." dans: PLoS ONE, Vol. 12, Issue 3, pp. e0173240, (2017) (PubMed).

Li, Cui, Yu, Li, Hou, Wang, Qin, Zhao, Yao, Zhao, Pei: "Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments." dans: PLoS ONE, Vol. 11, Issue 3, pp. e0151147, (2016) (PubMed).

Nie, Li, Yan, Wang, Zhao, Guo, Yin: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells." dans: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, (2011) (PubMed).

Détails sur BACE1

Antigène: BACE1 (Beta-secretase 1 (BACE1))

Autre désignation: BACE1 (BACE1 Produits)

Synonymes: anticorps ASP2, anticorps BACE, anticorps HSPC104, anticorps C76936, anticorps Bace, anticorps MGC145931, anticorps BACE1, anticorps zgc:77409, anticorps beta-secretase 1, anticorps beta-site APP cleaving enzyme 1, anticorps beta-site APP-cleaving enzyme 1, anticorps BACE1, anticorps Bace1, anticorps bace1

Sujet: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.

Poids moléculaire: 55764

ID gène: 23621

NCBI Accession: NP_001193978, NP_036236, NP_620427, NP_620428, NP_620429

UniProt: P56817