This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This PHLPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-31 amino acids from the N-terminal region of human PHLPP2.
anticorps PHLPPL, anticorps phlppl, anticorps AI481772, anticorps C130044A18Rik, anticorps Phlppl, anticorps RGD1562857, anticorps PH domain and leucine rich repeat protein phosphatase 2, anticorps PH domain and leucine rich repeat protein phosphatase 2 S homeolog, anticorps PHLPP2, anticorps phlpp2.S, anticorps phlpp2, anticorps Phlpp2
Sujet
PHLPP2 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1. This protein regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decrease cell proliferation. It also controls the phosphorylation of AKT3.