Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Homologie
B, M, Rat
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-162 amino acids from the Central region of human Activin Receptor Type IA (ACVR1).
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Mitu, Wang, Hirschberg: "BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury." dans: American journal of physiology. Renal physiology, Vol. 293, Issue 5, pp. F1641-8, (2007) (PubMed).
Weber, Teresi, Broelsch, Frilling, Eng: "A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma." dans: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 9, pp. 3584-91, (2006) (PubMed).
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.