MAP3K10 anticorps (C-Term)

N° du produit ABIN392424

Détail du produit anti-MAP3K10 anticorps

Antigène: MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10 (MAP3K10))

Épitope: AA 628-659, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP3K10 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This MLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 628-659 amino acids from the C-terminal region of human MLK2.

Clone: RB0986

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-MAP3K10 (ABIN392424)

Humphrey, Newcomb, Yu, Hao, Yu, Krajewski, Du, Jhala: "Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." dans: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22426-36, (2010) (PubMed).

Nagao, Hayashi: "Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease." dans: Journal of the neurological sciences, Vol. 281, Issue 1-2, pp. 51-4, (2009) (PubMed).

Détails sur MAP3K10

Antigène: MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10 (MAP3K10))

Autre désignation: MLK2 (MAP3K10 Produits)

Synonymes: anticorps MEKK10, anticorps MLK2, anticorps MST, anticorps BC028668, anticorps BC046514, anticorps Mlk2, anticorps mlk2, anticorps xmlk2, anticorps mitogen-activated protein kinase kinase kinase 10, anticorps mitogen activated protein kinase kinase kinase 10, anticorps mitogen-activated protein kinase kinase kinase 10 L homeolog, anticorps MAP3K10, anticorps Map3k10, anticorps map3k10.L

Sujet: MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.

Poids moléculaire: 103694

ID gène: 4294

NCBI Accession: NP_002437

UniProt: Q02779