PIM2 anticorps (C-Term)

N° du produit ABIN392442

Détail du produit anti-PIM2 anticorps

Antigène: PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))

Épitope: AA 277-308, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIM2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-308 amino acids from the C-terminal region of human PIM2.

Clone: RB01288

Isotype: Ig Fraction

Information d'application

Indications d'application: IP: 1:50~100. WB: 1:1000. WB: 1:1000. WB: 1:2000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PIM2 (ABIN392442)

Pogacic, Bullock, Fedorov, Filippakopoulos, Gasser, Biondi, Meyer-Monard, Knapp, Schwaller: "Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity." dans: Cancer research, Vol. 67, Issue 14, pp. 6916-24, (2007) (PubMed).

Détails sur PIM2

Antigène: PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))

Autre désignation: PIM2 (PIM2 Produits)

Synonymes: anticorps cb1068, anticorps fj47b05, anticorps pim2, anticorps wu:fj47b05, anticorps DXCch3, anticorps Pim-2, anticorps Pim-2 proto-oncogene, serine/threonine kinase, anticorps proviral integration site 2, anticorps pim2, anticorps PIM2, anticorps Pim2

Sujet: Pim proteins (Pim-1, Pim-2 and Pim-3) are oncogene-encoded serine/threonine kinases. Pim-2 is highly homologous to Pim-1 with similar oncogenic functions. Pim-2 overexpression promotes resistance to a host of apoptotic stimuli, its expression is negatively regulated by growth factor depletion. Increased levels of Pim-2 has also been observed in certain cancers.

Poids moléculaire: 34190

ID gène: 11040

NCBI Accession: NP_006866

UniProt: Q9P1W9