MYLK3 anticorps (N-Term)

N° du produit ABIN392494

Détail du produit anti-MYLK3 anticorps

Antigène: MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))

Épitope: AA 40-69, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYLK3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This MYLK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human MYLK3.

Clone: RB3066

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-MYLK3 (ABIN392494)

Rossi, Todd, Daniels, Bazan, Belayev: "Interferon Stimulated Gene 15 upregulation precedes the development of blood brain barrier disruption and cerebral edema after traumatic brain injury in young mice." dans: Journal of neurotrauma, (2015) (PubMed).

Rossi, Ralay Ranaivo, Patel, Chrzaszcz, Venkatesan, Wainwright: "Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase." dans: Journal of neuroscience research, Vol. 89, Issue 6, pp. 852-61, (2011) (PubMed).

Détails sur MYLK3

Antigène: MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))

Autre désignation: MYLK3 (MYLK3 Produits)

Synonymes: anticorps MLCK, anticorps MLCK2, anticorps caMLCK, anticorps D830007F02Rik, anticorps RGD1305801, anticorps myosin light chain kinase 3, anticorps MYLK3, anticorps Mylk3

Sujet: MLCK, a member of the Ser/Thr protein kinase family, is a calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.

Poids moléculaire: 88393

ID gène: 91807

NCBI Accession: NP_872299

UniProt: Q32MK0

Pathways: Regulation of Muscle Cell Differentiation