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PIK3R3 anticorps (C-Term)

PIK3R3 Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal RB1719 unconjugated
N° du produit ABIN392576
  • Antigène Voir toutes PIK3R3 Anticorps
    PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3))
    Épitope
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 316-346, C-Term
    Reactivité
    • 45
    • 34
    • 18
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 40
    • 4
    • 1
    • 1
    Lapin
    Clonalité
    • 36
    • 10
    Polyclonal
    Conjugué
    • 27
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PIK3R3 est non-conjugé
    Application
    • 29
    • 16
    • 14
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This PIK3R3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-346 amino acids from the C-terminal region of human PIK3R3.
    Clone
    RB1719
    Isotype
    Ig Fraction
  • Indications d'application
    IF: 1:100. WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Yang, Cheng, Zhou, Zhu, Hu, Yang: "Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K/mTOR in Human Osteosarcoma." dans: International journal of molecular sciences, Vol. 16, Issue 12, pp. 28635-46, (2016) (PubMed).

    Wang, Yang, Jin, Deng, Luo, Hu, Wang: "TGF-? regulates the proliferation of lung adenocarcinoma cells by inhibiting PIK3R3 expression." dans: Molecular carcinogenesis, (2014) (PubMed).

    Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." dans: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).

    Zhang, Huang, Yang, Greshock, Liang, Hasegawa, Giannakakis, Poulos, OBrien-Jenkins, Katsaros, Butzow, Weber, Coukos: "Integrative genomic analysis of phosphatidylinositol 3'-kinase family identifies PIK3R3 as a potential therapeutic target in epithelial ovarian cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 18 Pt 1, pp. 5314-21, (2007) (PubMed).

  • Antigène
    PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3))
    Autre désignation
    PIK3R3 (PIK3R3 Produits)
    Synonymes
    anticorps AA414954, anticorps p55pik, anticorps p55, anticorps p55-GAMMA, anticorps pik3r3, anticorps zgc:55564, anticorps zgc:85710, anticorps phosphoinositide-3-kinase regulatory subunit 3, anticorps phosphoinositide-3-kinase, regulatory subunit 3 (gamma), anticorps phosphoinositide-3-kinase, regulatory subunit 3b (gamma), anticorps PIK3R3, anticorps Pik3r3, anticorps pik3r3b
    Sujet
    PIK3R3 binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. It is a component of a heterodimer of p110 (catalytic) and p55 (regulatory) subunits. The protein is expressed at highest levels in brain and testis. Lower levels are detected in adipose tissue, kidney, heart, lung and skeletal muscle. The protein contains 2 SH2 domains.
    Poids moléculaire
    54448
    ID gène
    8503
    NCBI Accession
    NP_001107644, NP_003620
    UniProt
    Q92569
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