PLK3 anticorps (C-Term)

N° du produit ABIN392602

Détail du produit anti-PLK3 anticorps

Antigène: PLK3 (Polo-Like Kinase 3 (PLK3))

Épitope: AA 615-646, C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLK3 est non-conjugé

Application: Western Blotting (WB)

Homologie: Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PLK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 615-646 amino acids from the C-terminal region of human PLK3.

Clone: RB0875

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PLK3 (ABIN392602)

Zhang, Shi, Paddon, Hampong, Dai, Pelech: "B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1." dans: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 35726-34, (2004) (PubMed).

Détails sur PLK3

Antigène: PLK3 (Polo-Like Kinase 3 (PLK3))

Autre désignation: PLK3 (PLK3 Produits)

Synonymes: anticorps cnk, anticorps wu:fi35f10, anticorps fnk, anticorps prk, anticorps plx3, anticorps MGC89507, anticorps PLK2/3, anticorps NV15469, anticorps Plx3, anticorps CNK, anticorps FNK, anticorps PRK, anticorps Cnk, anticorps Fnk, anticorps polo-like kinase 3 (Drosophila), anticorps polo like kinase 3, anticorps polo-like kinase 3, anticorps polo-like kinase 3 S homeolog, anticorps polo-like kinase 3 L homeolog, anticorps Serine/threonine-protein kinase plk-3, anticorps plk3, anticorps PLK3, anticorps LOC100118436, anticorps plk3.S, anticorps plk3.L, anticorps Plk3, anticorps plk-3

Sujet: CNK, a member of the CDC5/Polo subfamily of Ser/Thr protein kinases, is involved in regulating M phase functions during the cell cycle. It may also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein. This membrane-associated protein binds to the calcium/integrin-binding protein (CIB). This interaction probably occurs via the POLO-box domain. Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. This protein exhibits a short half-live. In cells of hematopoietic origin, CNK is strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor. Cytokine and cellular adhesion trigger CNK induction. CNK is thought to be phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis The protein contains 2 POLO box domains.

Poids moléculaire: 71629

ID gène: 1263

NCBI Accession: NP_004064

UniProt: Q9H4B4

Pathways: Regulation of long-term Neuronal Synaptic Plasticity