TLK2 anticorps (AA 141-171)

N° du produit ABIN392686

Détail du produit anti-TLK2 anticorps

Antigène: TLK2 (Tousled-Like Kinase 2 (TLK2))

Épitope: AA 141-171

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLK2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This TLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-171 amino acids from the Central region of human TLK2.

Clone: RB3046

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur TLK2

Antigène: TLK2 (Tousled-Like Kinase 2 (TLK2))

Autre désignation: TLK2 (TLK2 Produits)

Synonymes: anticorps tlk2, anticorps MGC149057, anticorps HsHPK, anticorps PKU-ALPHA, anticorps wu:fi16h09, anticorps wu:fi30g12, anticorps zgc:136697, anticorps 4933403M19Rik, anticorps PKUalpha, anticorps Tlk, anticorps tousled like kinase 2, anticorps tousled-like kinase 2, anticorps tousled-like kinase 2 (Arabidopsis), anticorps tlk2, anticorps TLK2, anticorps Tlk2

Sujet: TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.

Poids moléculaire: 87661

ID gène: 11011

NCBI Accession: NP_001106178, NP_006843

UniProt: Q86UE8