PFKFB4 anticorps (AA 266-296)

N° du produit ABIN392786

Détail du produit anti-PFKFB4 anticorps

Antigène: PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))

Épitope: AA 266-296

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PFKFB4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PFKFB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-296 amino acids from the Central region of human PFKFB4.

Clone: RB04059

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:100. IHC-P: 1:250

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PFKFB4 (ABIN392786)

Ros, Flöter, Kaymak, Da Costa, Houddane, Dubuis, Griffiths, Mitter, Walz, Blake, Behrens, Brindle, Zamboni, Rider, Schulze: "6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells." dans: Oncogene, Vol. 36, Issue 23, pp. 3287-3299, (2017) (PubMed).

Gómez, Manzano, Figueras, Viñals, Ventura, Rosa, Bartrons, Navarro-Sabaté: "Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway." dans: American journal of physiology. Endocrinology and metabolism, Vol. 303, Issue 6, pp. E695-707, (2012) (PubMed).

Ros, Santos, Moco, Baenke, Kelly, Howell, Zamboni, Schulze: "Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival." dans: Cancer discovery, Vol. 2, Issue 4, pp. 328-43, (2012) (PubMed).

Yalcin, Clem, Simmons, Lane, Nelson, Clem, Brock, Siow, Wattenberg, Telang, Chesney: "Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases." dans: The Journal of biological chemistry, Vol. 284, Issue 36, pp. 24223-32, (2009) (PubMed).

Blum, Jacob-Hirsch, Amariglio, Rechavi, Kloog: "Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death." dans: Cancer research, Vol. 65, Issue 3, pp. 999-1006, (2005) (PubMed).

Détails sur PFKFB4

Antigène: PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))

Autre désignation: PFKFB4 (PFKFB4 Produits)

Synonymes: anticorps MGC69186, anticorps MGC81068, anticorps PFKFB4, anticorps zgc:123288, anticorps C230090D14, anticorps 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, anticorps 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 S homeolog, anticorps 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a, anticorps pfkfb4, anticorps pfkfb4.S, anticorps PFKFB4, anticorps pfkfb4a, anticorps f264, anticorps Pfkfb4

Sujet: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

Poids moléculaire: 54040

ID gène: 5210

NCBI Accession: NP_004558

UniProt: Q16877