This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This ITPKA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ITPKA.
anticorps IP3-3KA, anticorps IP3KA, anticorps inositol-trisphosphate 3-kinase A-like, anticorps Inositol-trisphosphate 3-kinase A, anticorps inositol-trisphosphate 3-kinase A, anticorps inositol 1,4,5-trisphosphate 3-kinase A, anticorps LOC564528, anticorps ip3ka, anticorps ITPKA, anticorps Itpka
Sujet
ITPKA regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68 % identical in the C-terminus region.