PTPN5 anticorps (N-Term)
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- Antigène Voir toutes PTPN5 Anticorps
- PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))
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Épitope
- AA 168-198, N-Term
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PTPN5 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogène
- This STEP / PTPN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-198 amino acids from the N-terminal region of human STEP / PTPN5.
- Clone
- RB00604
- Isotype
- Ig Fraction
- Top Product
- Discover our top product PTPN5 Anticorps primaire
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- Indications d'application
- WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Date de péremption
- 6 months
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- Antigène
- PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))
- Autre désignation
- STEP / PTPN5 (PTPN5 Produits)
- Synonymes
- anticorps STEP, anticorps Step, anticorps PTPSTEP, anticorps protein tyrosine phosphatase, non-receptor type 5, anticorps ptpn5, anticorps PTPN5, anticorps Ptpn5
- Sujet
- STEP (striatum-enriched phosphatase) is a neural-specific protein-tyrosine phosphatase, first isolated from the rat brain. The 537-amino acid predicted human protein as isolated from cDNA sequences is between 85 and 90 % identical to the mouse and rat sequences. In rat neuronal cell cultures, glutamate-mediated activation of N-methyl-D-aspartate (NMDA) receptors leads to the rapid but transient phosphorylation of extracellular signal-related kinase-2 (ERK2). NMDA-mediated influx of calcium, activates the calcium-dependent phosphatase calcineurin and the resulting dephosphorylation and activation of STEP. STEP then inactivatea ERK2 through tyrosine dephosphorylation and blocks translocation of the kinase to the nucleus. STEP plays a significant role in regulating the ERK activation and downstream signaling in neurons.
- Poids moléculaire
- 63538
- ID gène
- 84867
- NCBI Accession
- NP_001035059, NP_001265165, NP_001265167, NP_001265168, NP_008837, NP_116170
- UniProt
- P54829
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