DUSP6 anticorps (AA 58-89)

N° du produit ABIN392864

Détail du produit anti-DUSP6 anticorps

Antigène: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Épitope: AA 58-89

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DUSP6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DUSP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-89 amino acids from the Central region of human DUSP6.

Clone: RB05814

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:2000. WB: 1:500. WB: 1:2000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur DUSP6

Antigène: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Autre désignation: DUSP6 (DUSP6 Produits)

Synonymes: anticorps HH19, anticorps MKP3, anticorps PYST1, anticorps 1300019I03Rik, anticorps MKP-3, anticorps Mkp3, anticorps wu:fd99d09, anticorps mkp3, anticorps pyst1, anticorps DUSP6, anticorps dusp6, anticorps dual specificity phosphatase 6, anticorps dual specificity phosphatase 6 L homeolog, anticorps Dual specificity protein phosphatase 6, anticorps DUSP6, anticorps Dusp6, anticorps dusp6, anticorps dusp6.L, anticorps dus6

Sujet: DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for the DUSP6 gene.

Poids moléculaire: 42320

ID gène: 1848

NCBI Accession: NP_001937, NP_073143

UniProt: Q16828

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades