This Monoclonal antibody NP4D6 reacts with CD203c, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
Réactivité croisée (Details)
Species reactivity (tested):Human.
Attributs du produit
Synonyms: E-NPP 3, PDNP3, Phosphodiesterase I beta, PD-I beta, Ectonucleotide pyrophosphatase /phosphodiesterase family member 3, Phosphodiesterase I/nucleotide pyrophosphatase 3
CD203c, also known as ENPP-3, is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies.Synonyms: E-NPP 3, Ectonucleotide pyrophosphatase / phosphodiesterase family member 3, PD-I beta, PDNP3, Phosphodiesterase I beta, Phosphodiesterase I/nucleotide pyrophosphatase 3