PPP1R13B anticorps (Internal Region)
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- Antigène Voir toutes PPP1R13B Anticorps
- PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PPP1R13B est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificité
- This antibody is directed against ASPP1.
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. - Purification
- Affinity chromatography
- Immunogène
- Synthetic peptide corresponding to an internal sequence of human ASPP1
- Isotype
- IgG
- Top Product
- Discover our top product PPP1R13B Anticorps primaire
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- Indications d'application
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ELISA: 1/2,500 - 1/10,000. Western Blot: 1/500 - 1/3,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.3 mg/mL (by UV absorbance at 280 nm)
- Buffer
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
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- Antigène
- PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))
- Autre désignation
- PPP1R13B (PPP1R13B Produits)
- Synonymes
- anticorps ASPP1, anticorps p53BP2-like, anticorps p85, anticorps AI449786, anticorps AW545810, anticorps Tp53bp2, anticorps Trp53bp2, anticorps protein phosphatase 1 regulatory subunit 13B, anticorps protein phosphatase 1, regulatory subunit 13B, anticorps protein phosphatase 1 regulatory subunit 13B L homeolog, anticorps protein phosphatase 1, regulatory subunit 13Bb, anticorps protein phosphatase 1, regulatory (inhibitor) subunit 13B, anticorps PPP1R13B, anticorps Ppp1r13b, anticorps ppp1r13b.L, anticorps ppp1r13bb, anticorps ppp1r13b
- Sujet
- ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, iASPP functionally inactivates p53. ASPPs may also regulate p63- and p73-mediated apoptosis. Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3. Not all cell cycle arrest genes are affected, such as p21. Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.Synonyms: ASPP1, Apoptosis-stimulating of p53 protein 1, KIAA0771, Protein phosphatase 1 regulatory subunit 13B
- ID gène
- 23368
- NCBI Accession
- NP_056131
- UniProt
- Q96KQ4
- Pathways
- Signalisation p53
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