FERMT3 anticorps (C-Term)

N° du produit ABIN453975

Détail du produit anti-FERMT3 anticorps

Antigène: FERMT3 (Fermitin Family Member 3 (FERMT3))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp FERMT3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This URP2 antibody (AP09600PU-N) is expected to recognize both isoforms (NP_113659.3, NP_848537.1).

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat and Canine (Dog).
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence C-ERARGEELDED, from the C-Terminus of kindlin-3/URP2 (NP_113659.3, NP_848537.1).

Information d'application

Indications d'application: Peptide ELISA: URP2 Antibody Detection limit dilution: 1/2000. Western blot: 1-3 μg/mL. Approx 75 kDa band observed in Human Peripheral BloodMononucleocytes lysates (calculated MW of 75.5 kDa according to NP_113659.3).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur FERMT3

Antigène: FERMT3 (Fermitin Family Member 3 (FERMT3))

Autre désignation: FERMT3 (FERMT3 Produits)

Synonymes: anticorps C79673, anticorps Kindlin3, anticorps RGD1310168, anticorps MGC69069, anticorps MGC88900, anticorps KIND3, anticorps MIG-2, anticorps MIG2B, anticorps UNC112C, anticorps URP2, anticorps URP2SF, anticorps zgc:64101, anticorps fermitin family member 3, anticorps fermitin family member 3 L homeolog, anticorps fermitin family member 3b, anticorps Fermt3, anticorps fermt3.L, anticorps fermt3, anticorps FERMT3, anticorps fermt3b

Sujet: URP2 is an essential element for platelet integrin activation in hemostasis and thrombosis. Platelets lacking the adhesion plaque protein URP2 cannot activate integrins despite normal Talin expression. As a direct consequence, URP2 deficiency results in severe bleeding and resistance to arterial thrombosis. URP2 binds directly bind to regions of beta-integrin tails and triggers integrin activation.Synonyms: Fermitin family homolog 3, KIND3, Kindlin-3, MIG2-like protein, MIG2B, URP2, Unc-112-related protein 2

ID gène: 83706

NCBI Accession: NP_113659

UniProt: Q86UX7