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NFAT1 anticorps (Internal Region)
NFAT1
Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache)
WB, IHC (p), EIA
Hôte: Chèvre
Polyclonal
unconjugated
Détail du produit anti-NFAT1 anticorps
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Antigène
Voir toutes NFAT1 Anticorps
NFAT1
(Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))
Épitope
Tous les épitopes à travers NFAT1 Anticorps.
Internal Region
Reactivité
Toutes les réactivités sur NFAT1 Anticorps
Humain, Souris, Rat, Chien, Boeuf (Vache)
Hôte
Toutes les hôtes sur NFAT1 Anticorps
Chèvre
Clonalité
Toutes les clonalités sur NFAT1 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers NFAT1 Anticorps
Cet anticorp NFAT1 est non-conjugé
Application
Tous les applications à travers NFAT1 Anticorps.
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Séquence
c-QQFRTGLSSP DARYQ
Specificité
This antibody is expected to recognize all three reported isoforms of NFATC2 (NP_036472.2, NP_775114.1, NP_001129493.1).
Réactivité croisée (Details)
Species reactivity (expected):Mouse, Rat, Canine, Bovine. Species reactivity (tested):Human.
Purification
Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Immunogène
Peptide with sequence from the internal region of the protein sequence according to NP_036472.2, NP_775114.1, NP_001129493.1. Genename: NFATC2
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Alternatives
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anti-Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) (C-Term) antibody
NFAT1
Reactivité: Humain, Souris, Rat, Chien, Cheval, Cobaye, Lapin, Porc, Singe, Roussette (Chauve-souris)
WB, IHC, IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
anti-Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) (C-Term) antibody
NFAT1
Reactivité: Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Lapin, Poisson zèbre (Danio rerio)
WB, IHC
Hôte: Lapin
Polyclonal
unconjugated
Information d'application
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Indications d'application
Peptide ELISA: 1/64000. Western blot: 0.3 - 1 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Concentration
0.5 mg/mL
Buffer
Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Détails sur NFAT1
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Antigène
NFAT1
(Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))
Autre désignation
NFATC2 (NFAT1 Produits )
Synonymes
anticorps NFATC2, anticorps AI607462, anticorps NF-ATc2, anticorps NFAT1, anticorps NFAT1-D, anticorps Nfatp, anticorps NFATP, anticorps nuclear factor of activated T-cells 2, anticorps nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2, anticorps NFATC2, anticorps nfatc2, anticorps Nfatc2
Sujet
Nuclear factor of activated T cells (NFAT) is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. NFAT1 (also known as NFATc2 or NFATp) is a member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT1, leading to its translocation to the nucleus and activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT1 has been shown to be important in the regulation of its transcriptional activity.Synonyms: NFAT pre-existing subunit, NFAT-1, NFATC2, NFATP, Nuclear factor of activated T-cells, T-cell transcription factor NFAT1, cytoplasmic 2
ID gène
4773
NCBI Accession
NP_036472
UniProt
Q13469
Pathways
Signalisation RTK , Signalisation WNT , Fc-epsilon Receptor Signaling Pathway , VEGF Signaling , BCR Signaling
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