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PRR7 anticorps (C-Term, Intracellular)

PRR7 Reactivité: Humain, Souris, Rat WB, ICC Hôte: Souris Monoclonal TRAP3-10 unconjugated
N° du produit ABIN457438
  • Antigène Voir toutes PRR7 Anticorps
    PRR7 (Proline Rich 7 (Synaptic) (PRR7))
    Épitope
    • 9
    • 8
    • 7
    • 1
    • 1
    • 1
    C-Term, Intracellular
    Reactivité
    • 20
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 18
    • 2
    Souris
    Clonalité
    • 18
    • 2
    Monoclonal
    Conjugué
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp PRR7 est non-conjugé
    Application
    • 20
    • 13
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC)
    Specificité
    The mouse monoclonal antibody TRAP3/10 recognizes an epitope located in the C-terminal part of the intracellular domain of PRR7/TRAP3 (amino acids 126-253 of human PRR7 / TRAP3), a 28 kDa proline-rich membrane protein presumably associated with NMDA receptor complex.
    Réactivité croisée (Details)
    Human, Mouse, Rat
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Recombinant C-terminal half of the intracellular domain of human PRR7/TRAP3 (amino acids 126-253)
    Clone
    TRAP3-10
    Isotype
    IgG2a
  • Indications d'application
    Immunocytochemistry: Recommended dilution: 10 μg/mL, cell culture fixed with 4 % paraformaldehyde, permeabilized with 0.1 % Triton-X100.
    Western blotting: Recommended dilution: 1 μg/mL, positive control: murine brain lysate (red. Laemmli buffer).
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Hrdinka, Dráber, Stepánek, Ormsby, Otáhal, Angelisová, Brdicka, Paces, Horejsí, Drbal: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." dans: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).

  • Antigène
    PRR7 (Proline Rich 7 (Synaptic) (PRR7))
    Autre désignation
    PRR7 / TRAP3 (PRR7 Produits)
    Synonymes
    anticorps PRR7, anticorps XM_484263, anticorps proline rich 7, synaptic, anticorps proline rich 7 (synaptic), anticorps proline rich 7 (synaptic) L homeolog, anticorps PRR7, anticorps prr7, anticorps prr7.L, anticorps Prr7
    Sujet
    Proline rich 7, synaptic,PRR7/TRAP3 (proline-rich 7, transmembrane adaptor protein 3) is a 28 kDa transmembrane adaptor protein ubiquitously expressed at low level (most in brain). Its amino acid sequence is extremely conserved among mammalian and other species. PRR7/TRAP3 contains potential palmitoylation motif and is found in lipid rafts. It is a part of the complex postsynaptic density fraction in neurons and associates with PSD-95, NMDA receptor and probably other proteins. The intracellular domain of PRR7/TRAP3 contains several tyrosines, a proline-rich sequence, and a C-terminal PDZ-binding motif. So far nothing is known about function of this protein. It may be involved in regulation of some receptor signaling and in formation of neurologic and immunologic synapse.,TRAP3
    ID gène
    80758
    UniProt
    Q8TB68
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