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Prekallikrein anticorps

PK Reactivité: Humain IEP, ID Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN458043
  • Antigène Voir toutes Prekallikrein (PK) Anticorps
    Prekallikrein (PK)
    Reactivité
    Humain
    Hôte
    • 7
    • 3
    • 2
    Chèvre
    Clonalité
    • 9
    • 2
    Polyclonal
    Conjugué
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Prekallikrein est non-conjugé
    Application
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunoelectrophoresis (IEP), Immunodiffusion (ID)
    Specificité
    The antiserum does not cross-react with any other human plasma proteins as tested in gel-diffusion techniques. Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins, since homologous proteins of different species frequently share antigenic determinants. of this antiserum has not been tested in detail, however in double radial immunodiffusion a reaction with monkey has been observed.
    Attributs du produit
    Precipitating polyclonal goat antiserum to human prekallikrein
    Purification
    Adsorption: Immunoaffinity adsorbed using insolubilized antigens as required, to eliminate antibodies reacting with other human serum proteins. The use of insolubilized adsorption antigens prevents the presence of excess adsorbent protein or immune complexes in the antiserum.
    Immunogène
    Prekallikrein is a single-chain. Glycoprotein (MW 88,000) present in inactive form in plasma, pancreas and intestine. Prekallikrein is activated to kallikrein by Factor XIIa which in turn results from activation of Factor XII by prekallikrein combined with Factor XII and high-molecular-weight kininogen (HMWK). It releases kinins from the low-molecular-weight and the high-molecular-weight kininogen. Highly purified molecular weight kininogen isolated from pooled plasma. Freund’s complete adjuvant is used in the first step of the immunization procedure.
    Isotype
    IgG
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    Discover our top product PK Anticorps primaire
  • Indications d'application
    As precipitating antiserum in electroimmunodiffusion, immunoelectrophoresis and radial immunodiffusion. This does not exclude the use of the antiserum in more sensitive techniques if proper controls are included.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Total protein and IgG concentration in the antiserum are comparable to those of pooled normal goat serum. No foreign proteins added. Antibody titre: Precipitin titre not less than 1:32 when tested against normal human plasma in agar block immunodiffusion
    Buffer
    Delipidated, heat inactivated, lyophilized, stable whole serum.
    Agent conservateur
    Without preservative
    Stock
    4 °C/-20 °C
    Stockage commentaire
    The lyophilized antiserum is shipped at ambient temperature and may be stored at +4°C, prolonged storage at or below -20°C. Reconstitute the lyophilized antiserum by adding 1 ml sterile distilled water. Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum. Diluted antiserum should be stored at +4°C, not refrozen, and preferably used the same day.
  • Antigène
    Prekallikrein (PK)
    Autre désignation
    Prekallikrein (PK Produits)
    Synonymes
    anticorps APS, anticorps KLK2A1, anticorps PSA, anticorps hK3, anticorps kallikrein related peptidase 3, anticorps KLK3
    Sujet
    The defined antibody specificity is to prekallikrein. Plasma kallikrein is present in two slightly different forms. This corresponds with two different forms of kallikrein after prekallikrein has been activated by Factor XIIa. Inactive plasma prekallikrein and active kallikrein may react with the antiserum. Although prekallikrein exhibits structural homology to Factor XI, the antiserum does not react with Factor XI
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