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Methotrexate anticorps

MTX EIA Hôte: Mouton Polyclonal unconjugated
N° du produit ABIN487772
  • Antigène Voir toutes Methotrexate (MTX) Anticorps
    Methotrexate (MTX)
    Reactivité
    Veuillez nous consulter SVP
    Hôte
    • 3
    Mouton
    Clonalité
    • 2
    Polyclonal
    Conjugué
    • 3
    Cet anticorp Methotrexate est non-conjugé
    Application
    • 3
    • 1
    • 1
    Enzyme Immunoassay (EIA)
    Purification
    Ig Fraction
    Immunogène
    Methotrexate -BSA
    Isotype
    IgG
    Top Product
    Discover our top product MTX Anticorps primaire
  • Indications d'application
    ELISA: 2.5 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    7.74 mg/mL (U.V.abs at 280nm)
    Buffer
    20 mM Phosphate, 150 mM Sodium Chloride, pH 7.2 containing 0.09 % Sodium Azide as preservative
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
  • Antigène
    Methotrexate (MTX)
    Autre désignation
    Methotrexate (MTX Produits)
    Classe de substances
    Amino Acid
    Sujet
    Methotrexate (rINN) abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases and as an abortifacient in the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. The affinity of methotrexate for DHFR is about one thousand-fold that of folate for DHFR. Methotrexate acts specifically during DNA and RNA synthesis, and thus it is cytotoxic during the S-phase of the cell cycle. Logically, it therefore has a greater toxic effect on rapidly dividing cells which replicate their DNA more frequently, and thus inhibits the growth and proliferation of these non-cancerous cells. Lower doses of methotrexate have been shown to be very effective for the management of rheumatoid arthritis, Crohn's disease, and psoriasis.Synonyms: 4-amino-10-methylpteroyl-L-glutamic acid
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