ADC anticorps (AA 111-301)

N° du produit ABIN4886479

Détail du produit anti-ADC anticorps

Antigène: ADC (Arginine Decarboxylase (ADC))

Épitope: AA 111-301

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Antizyme inhibitor 2(AZIN2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Antizyme inhibitor 2(AZIN2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: antizyme inhibitor 2
Protein Name: Antizyme inhibitor 2

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human AZIN2 recombinant protein (Position: C111-Q301). Human AZIN2 shares 89.4% amino acid (aa) sequence identity with mouse AZIN2.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur ADC

Antigène: ADC (Arginine Decarboxylase (ADC))

Autre désignation: AZIN2 (ADC Produits)

Synonymes: anticorps MGC134604, anticorps azi2, anticorps odc2, anticorps odc-p, anticorps odc1l, anticorps xodc2, anticorps ADC, anticorps AZI2, anticorps ODC-p, anticorps ODC1L, anticorps 4933429I20Rik, anticorps AZIN2, anticorps Azi2, anticorps B930082O19, anticorps Odcp, anticorps RGD1564776, anticorps odc1-b, anticorps arginine decarboxylase, anticorps antizyme inhibitor 2, anticorps biosynthetic arginine decarboxylase SpeA, anticorps biosynthetic arginine decarboxylase SpeA (ADC), anticorps pyruvoyl-dependent arginine decarboxylase, anticorps antizyme inhibitor 2 S homeolog, anticorps AZIN2, anticorps azin2, anticorps adc, anticorps speA, anticorps Mrub_2839, anticorps MMAH_RS09440, anticorps Arnit_1968, anticorps Mesil_3114, anticorps Trad_0080, anticorps Spirs_3255, anticorps LOC100233080, anticorps Azin2, anticorps azin2.S

Sujet: Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.

Synonyms: ADC | Antizyme inhibitor 2 | ArgDC | Arginine decarboxylase | AZI2 | ODC-p | ODC-paralogue | ODC1L | ODCp | Q96A70

ID gène: 113451

UniProt: Q96A70