TLR4 anticorps (N-Term)
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- Antigène Voir toutes TLR4 Anticorps
- TLR4 (Toll-Like Receptor 4 (TLR4))
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Épitope
- AA 50-68, N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TLR4 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Fonction
- Rabbit IgG polyclonal antibody for Toll-like receptor 4(TLR4) detection. Tested with WB, IHC-P in Human.
- Séquence
- DNLPFSTKNL DLSFNPLRH
- Réactivité croisée (Details)
- No cross reactivity with other proteins.
- Attributs du produit
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Rabbit IgG polyclonal antibody for Toll-like receptor 4(TLR4) detection. Tested with WB, IHC-P in Human.
Gene Name: toll-like receptor 4
Protein Name: Toll-like receptor 4 - Purification
- Immunogen affinity purified.
- Immunogène
- A synthetic peptide corresponding to a sequence at the N-terminus of human TLR4(50-68aa DNLPFSTKNLDLSFNPLRH).
- Isotype
- IgG
- Top Product
- Discover our top product TLR4 Anticorps primaire
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- Indications d'application
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. - Commentaires
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- Agent conservateur
- Sodium azide, Thimerosal (Merthiolate)
- Précaution d'utilisation
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner." dans: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 231, (2018) (PubMed).
: "The protective effects of magnolol on acute trinitrobenzene sulfonic acid‑induced colitis in rats." dans: Molecular medicine reports, Vol. 17, Issue 3, pp. 3455-3464, (2018) (PubMed).
: "Lipopolysaccharide enhances TGF-β1 signalling pathway and rat pancreatic fibrosis." dans: Journal of cellular and molecular medicine, Vol. 22, Issue 4, pp. 2346-2356, (2018) (PubMed).
: "Acetylpuerarin protects against OGD-induced cell injury in BV2 microglia by inhibiting HMGB1 release." dans: Die Pharmazie, Vol. 73, Issue 2, pp. 92-97, (2018) (PubMed).
: "Rho Kinase Type 1 (ROCK1) Promotes Lipopolysaccharide-induced Inflammation in Corneal Epithelial Cells by Activating Toll-Like Receptor 4 (TLR4)-Mediated Signaling." dans: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 3514-3523, (2018) (PubMed).
: "Responses of Intestinal Mucosal Barrier Functions of Rats to Simulated Weightlessness." dans: Frontiers in physiology, Vol. 9, pp. 729, (2018) (PubMed).
: "Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice." dans: Pain, Vol. 157, Issue 4, pp. 806-17, (2017) (PubMed).
: "Knockdown of versican V1 induces a severe inflammatory response in LPS-induced acute lung injury via the TLR2-NF-κB signaling pathway in C57BL/6J mice." dans: Molecular medicine reports, Vol. 13, Issue 6, pp. 5005-12, (2017) (PubMed).
: "Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir." dans: International journal of molecular sciences, Vol. 17, Issue 6, (2017) (PubMed).
: "Phospholipase A2 of Peroxiredoxin 6 Plays a Critical Role in Cerebral Ischemia/Reperfusion Inflammatory Injury." dans: Frontiers in cellular neuroscience, Vol. 11, pp. 99, (2017) (PubMed).
: "Allicin Alleviates Reticuloendotheliosis Virus-Induced Immunosuppression via ERK/Mitogen-Activated Protein Kinase Pathway in Specific Pathogen-Free Chickens." dans: Frontiers in immunology, Vol. 8, pp. 1856, (2017) (PubMed).
: "Lipopolysaccharide induces acute bursal atrophy in broiler chicks by activating TLR4-MAPK-NF-κB/AP-1 signaling." dans: Oncotarget, Vol. 8, Issue 65, pp. 108375-108391, (2017) (PubMed).
: "Increased Thymic Cell Turnover under Boron Stress May Bypass TLR3/4 Pathway in African Ostrich." dans: PLoS ONE, Vol. 10, Issue 6, pp. e0129596, (2016) (PubMed).
: "The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-?B pathway activation." dans: International immunopharmacology, Vol. 23, Issue 1, pp. 294-303, (2015) (PubMed).
: "Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor ?B and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis." dans: Gut and liver, Vol. 9, Issue 3, pp. 411-6, (2015) (PubMed).
: "Dual-color immunofluorescent labeling with quantum dots of the diabetes-associated proteins aldose reductase and Toll-like receptor 4 in the kidneys of diabetic rats." dans: International journal of nanomedicine, Vol. 10, pp. 3651-62, (2015) (PubMed).
: "High glucose induces and activates Toll-like receptor 4 in endothelial cells of diabetic retinopathy." dans: Diabetology & metabolic syndrome, Vol. 7, pp. 89, (2015) (PubMed).
: "Expression of TLR2/4 in the sperm-storing oviduct of the Chinese soft-shelled turtle Pelodiscus sinensis during hibernation season." dans: Ecology and evolution, Vol. 5, Issue 19, pp. 4466-79, (2015) (PubMed).
: "Upregulation of Toll-like receptor 2 expression in colorectal cancer infected by human cytomegalovirus." dans: Oncology letters, Vol. 9, Issue 1, pp. 365-370, (2014) (PubMed).
: "Ligusticum wallichii Extract Inhibited the Expression of IL-1? after AMI in Rats." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 620359, (2014) (PubMed).
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Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner." dans: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 231, (2018) (PubMed).
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- Antigène
- TLR4 (Toll-Like Receptor 4 (TLR4))
- Autre désignation
- TLR4 (TLR4 Produits)
- Synonymes
- anticorps ARMD10, anticorps CD284, anticorps TLR-4, anticorps TOLL, anticorps Lps, anticorps Ly87, anticorps Ran/M1, anticorps Rasl2-8, anticorps toll like receptor 4, anticorps toll-like receptor 4, anticorps TLR4, anticorps Tlr4
- Sujet
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TLR4, Toll-like receptor 4, is a protein that in humans is encoded by the TLR4 gene. TLR 4 is a toll-like receptor. TLR4, the human homolog of Drosophila Toll, is a type I transmembrane protein with an extracellular domain consisting of a leucine-rich repeat region and an intracellular domain homologous to that of human interleukin-1 receptor. The TLR4 gene is mapped to chromosome 9q32-q33 by fluorescence in situ hybridization.It detects lipopolysaccharide from Gram-negative bacteria and is thus important in the activation of the innate immune system.The protein encoded by this gene is a member of the Toll-like receptor(TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns(PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Synonyms: ARMD10 antibody|CD284 antibody|CD284 antigen antibody|Homolog of Drosophila toll antibody|hToll antibody|TLR 4 antibody|TLR4 antibody|TLR4_HUMAN antibody|Toll(Drosophila) homolog antibody|TOLL antibody|Toll Endotoxin Hyporesponsiveness antibody|Toll like receptor 4 antibody|Toll like receptor 4 precursor antibody|Toll-like receptor 4 antibody - UniProt
- O00206
- Pathways
- Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
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