beta Amyloid anticorps (AA 221-270)
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- Antigène Voir toutes beta Amyloid (Abeta) Anticorps
- beta Amyloid (Abeta) (Amyloid beta (Abeta))
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Épitope
- AA 221-270
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp beta Amyloid est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Fonction
- Amyloid-β is a protein encoded by the APP gene which is approximately 86,9 kDa. Amyloid-β is localised to the cell membrane. It is involved in activated TLR4 signalling, peptide ligand-binding receptors and A-beta pathways including plaque formation and APP metabolism. It functions as a cell surface receptor that performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. It plays a role in cell mobility and transcription regulation through protein-protein interactions. Amyloid-β is expressed in the cerebrospinal fluid, brain, liver and all foetal tissues. Mutations in the APP gene may be implicated in Alzheimer disease. STJ98585 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody detects endogenous levels of Amyloid-β.
- Specificité
- Amyloid-β Polyclonal Antibody detects endogenous levels of Amyloid-β
- Attributs du produit
- Rabbit Polyclonal to Amyloid-β.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogène
- Synthesized peptide derived from Amyloid-beta
- Isotype
- IgG
- Top Product
- Discover our top product Abeta Anticorps primaire
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- Indications d'application
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WB 1:500-2000
ELISA 1:10000-20000 - Commentaires
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Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra-striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Antigène
- beta Amyloid (Abeta) (Amyloid beta (Abeta))
- Autre désignation
- Amyloid-beta (Abeta Produits)
- Synonymes
- anticorps AAA, anticorps ABETA, anticorps ABPP, anticorps AD1, anticorps APPI, anticorps CTFgamma, anticorps CVAP, anticorps PN-II, anticorps PN2, anticorps aaa, anticorps abeta, anticorps abpp, anticorps ad1, anticorps appi, anticorps ctfgamma, anticorps cvap, anticorps pn2, anticorps Abeta, anticorps Abpp, anticorps Adap, anticorps Ag, anticorps Cvap, anticorps E030013M08Rik, anticorps betaApp, anticorps amyloid beta precursor protein, anticorps amyloid beta (A4) precursor protein, anticorps APP, anticorps app, anticorps App
- ID gène
- 351
- UniProt
- P05067
- Pathways
- Inflammasome
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