MLKL anticorps (pSer358)
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- Antigène Voir toutes MLKL Anticorps
- MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
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Épitope
- pSer358
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp MLKL est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Fonction
- MLKL is a protein encoded by the MLKL gene which is approximately 54,4 kDa. MLKL is localised to the cell membrane and cytoplasm. It is involved in the dimerization of procaspase-8, the TNF signalling pathway, apoptosis and autophagy. This protein falls under the protein kinase superfamily. It plays a critical role in tumour necrosis factor-induced necroptosis which is a programmed cell death process. It does this via interaction with the receptor-interacting protein 3 which is a key signalling molecule in necroptosis pathway. MLKL is expressed in the heart, intestine and lung. STJ97776 was developed from clone 6F8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen MLKL. This primary antibody specifically binds to endogenous MLKL protein which only binds about S358 when S358 is phosphorylated.
- Specificité
- Phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8) detects endogenous levels of MLKL
- Attributs du produit
- Mouse Monoclonal to phospho-MLKL (S358).
- Purification
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- Immunogène
- synthetic peptide derived from phospho-MLKL (S358)
- Clone
- 6F8
- Isotype
- IgG1
- Top Product
- Discover our top product MLKL Anticorps primaire
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- Indications d'application
- IHC 1:100-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Antigène
- MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
- Autre désignation
- MLKL (MLKL Produits)
- Synonymes
- anticorps MLKL, anticorps 9130019I15Rik, anticorps mixed lineage kinase domain like pseudokinase, anticorps mixed lineage kinase domain-like, anticorps MLKL, anticorps mlkl, anticorps Mlkl
- ID gène
- 197259
- UniProt
- Q8NB16
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