TOR1A anticorps

N° du produit ABIN4908959

Détail du produit anti-TOR1A anticorps

Antigène: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TOR1A est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogène: Purified His-tagged DYT1 protein(Fragment) was used to produced this monoclonal antibody.

Clone: 3C3

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TOR1A

Antigène: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Autre désignation: DYT1 (TOR1A Produits)

Synonymes: anticorps Dyt1, anticorps DQ2, anticorps DYT1, anticorps torsinA, anticorps torsin family 1, member A, anticorps torsin family 1 member A, anticorps torsin family 1, member A (torsin A), anticorps Tor1a, anticorps TOR1A

Sujet:

Synonyms: DQ2, DYT1, Torsin-1A, Dystonia 1 protein, Torsin ATPase-1A, Torsin family 1 member A, TOR1A, TA, TORA

Background: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.

ID gène: 1861

UniProt: O14656

Pathways: SARS-CoV-2 Protein Interactome